The use of new approach methodologies (NAMs) to derive extrapolation factors and evaluate developmental neurotoxicity for human health risk assessment

Full Peer Review Meeting:  EPA held a public meeting of the FIFRA Scientific Advisory Panel on Sept 15-17, 2020 to consider and review the use of new approach methodologies (NAMs) to derive extrapolation factors and evaluate developmental neurotoxicity for human health risk assessment (read the Federal Register notice). 

Preparatory Virtual Meeting: EPA held a preparatory virtual meeting for the SAP members and the public to comment on and ask questions regarding the scope and clarity of the draft charge questions to be used for the peer review on August 25, 2020.  View the agenda and the presentation for the August 25 meeting.

Meeting Materials: 

Click here for the agenda.

Click here for the charge questions.

Click here for the Meeting Minutes and Final Report.

Other materials, including EPA's background paper, are available for public comment in the EPA docket for this meeting, except for the following ZIP files which are available below:

• The nam_public_code_may2020.zip (zip) file (32 MB) ] contains the statistical analyses of development neurotoxicity new approach methodologies (NAMs) described in Section 2.3.4-2.3.6 of the Agency’s Issue Paper and a ReadMe file with zip folder details.
• The CEBanalysesSept2020_sap.zip (zip) p file (10 MB) includes the statistical analyses of in vitro inhibition kinetics data described in Section 3.2.2 and Section 3.3 of the Agency’s Issue Paper and a ReadMe file with zip folder details.
• The ICFstatAnalysis.zip (zip)  file (4 MB) includes ICF revised statistical models using Cholesky root parameterization of the covariance matrices and a ReadMe file with the zip folder details .

For additional information contact the DFO, Tamue Gibson at [email protected] or 202-564-7642. Contact Us to ask a question, provide feedback, or report a problem.