4th Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review

Date and Time

Tuesday, October 16, 2018
8:15 am - 5:00 pm EDT

Location

109 TW Alexander Dr
Auditorium C111A-C
Durham, NC 27709
United States

Event Host

U.S. EPA

Event Type

Webinar

Description

This will be the final STAR meeting with all 4 OCM Centers and their EPA colleagues. The Purpose of this meeting is to review their overall accomplishments, especially as they can be applied towards utilitarian risk assessment purposes. We will also be introduced to the new research projects from the Advancing Actionable Alternatives to Vertebrate Animal Testing for Chemical Safety Assessment RFA. Presentations will allow time for questions and discussion of challenges to the research’s practical applications.

Agenda
8:15 a.m.	Registration
8:30 a.m.	Welcome and Introduction Jeff Frithsen, EPA, Chemical Safety for Sustainability Research Program Director
9:00 a.m.	Progress and Next Steps in Making Organ-on-chip Technologies Amenable to Toxicity Testing Shane Hutson, Vanderbilt University, Vanderbilt-Pittsburgh Resource for Organotypic Models for Predictive Toxicology (VPROMPT)
9:40 a.m.	Progress and Next Steps in Human Models for Analysis of Pathways Bill Murphy, University of Wisconsin Madison, Human Models for analysis of Pathways (HMAPs) Center
10:20 a.m.	Break
10:55 a.m.	Organotypic Cultures and Assessment of AOP's: Importance of Medium Through Put Assays for Reducing Animal Use Elaine Faustman, University of Washington, Predictive Toxicology Center for Organotypic Cultures and Assessment of AOP's for Engineered Nanomaterials
11:35 a.m.	Microphysiological Systems that Fill Data Gaps in Human Health Assessments Ivan Rusyn, Texas A&M University, Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and In-vitro-to-in-vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments Center
12:15 p.m.	Lunch
1:15 p.m.	Update and Challenges to ORD's Virtual Tissue Modeling Efforts Sid Hunter, Chief of the EPA ORD-Center for Computational Toxicology and Exposure (CCTE), Biomolecular & Computational Toxicology Division (BCTD), Advance Experimental Toxicology Models Branch (AETMB)
1:40 p.m.	Translation and Implementation of New Approach Methodologies Maureen Gwinn, Division Director, EPA ORD-CCET-BCTD
2:00 p.m.	Break
2:15 p.m.	Update on ORD's Stem Cell Modeling Efforts Todd Zurlinden, EPA ORD-CCTE-BCTD-CTBB
2:45 p.m.	Skeletal Teratogenicity of Industrial and Environmental Chemicals Predicted with Human Pluripotent Stem Cells In Vitro Nochole zurNiden, University of California - Riverside
3:00 p.m.	Multiplexed Human Brain Sphere Developmental Neurotoxicity Test for Six Key Events of Neural Development Lena Smirnova, Johns Hopkins University
3:15 p.m.	A Neurovascular Unit on Chip for reducing Animals in Organophosphate Neurotoxicology David Cliffel, Vanderbilt University
3:30 p.m.	Instrumenting Phinotyupic Immunological Responses to Toxicants that Threaten Human Reproduction Kevin Osteen, Vanderbilt University
3:35 p.m.	Reducing the Reliance on Early-life Stage Testing with Relevance to Euryhaline Fishes: Development and Implementation fo In-vitro Assays Predictive of early Life Stage Toxicity and Population-level Effects in Mendia Beryllina Kaly Major, Post-Doc, Oregon State University
4:00 p.m.	Panel Discussion; Remaining Challenges to the Development and Implementation of Alternative Test Methods OCM Center Investigators and EPA Senior Scientists

Meeting Files

EPA Introduction (PDF)(10 pp, 1 MB, 12/17/2019)
Progress and Next Steps - Shane Hutson (PDF)(52 pp, 13 MB, 10/29/2019)
Microphysiological systems that fill data gaps in human health assessments - Ivan Rusyn (PDF)(32 pp, 5 MB, 10/16/2019)
Human Models for Analysis of Pathways (Human MAPs) Center - Bill Murphy (PDF)(51 pp, 15 MB, 12/18/2019)
Update on ORD's Stem Cell Modeling Efforts (PDF)(14 pp, 2 MB, 12/18/2019)
Translation and Implementation of NAMs (PDF)(12 pp, 1 MB, 12/18/2019)