When and where should an air carrier report a release?

When and where should an air carrier report a release?  For instance should the release be reported to the state where the release occurred or to the airport of destination?

Since aircraft should have radio communication capabilities, the report should be given to the state(s) likely to be affected by the release as soon as possible after the release.  Reporting at the destination will not necessarily enable the provision of timely response to the affected areas.